ARTHROTEC
Generic Name: diclofenac and misoprostol (dye KLOE fen ak and mye so PROST ole) Brand Names: Arthrotec
Take Arthrotec® tablets by mouth. Follow the directions on the prescription label. Swallow tablets whole with a full glass of water; take tablets in an upright or sitting position. Do not crush or chew tablets. Taking a sip of water first, before taking the tablets, may help you swallow them. If possible take bedtime doses at least 10 minutes before lying down. It is better to take Arthrotec® with food. Take your doses at regular intervals. Do not take your medicine more often than directed. DICLOFENAC; MISOPROSTOL is a combination of two drugs. Diclofenac is an antiinflammatory drug and reduces the joint pain, stiffness, inflammation, or swelling caused by rheumatoid arthritis (rheumatism) or osteoarthritis. Misoprostol is added to diclofenac to help prevent some of the adverse effects of diclofenac on the stomach. Generic Arthrotec® tablets are not yet available.  Diclofenac and misoprostol (dye-KLOE-fen-ak and mye-soe-PROST-ole ) combination is used for patients with arthritis who may develop stomach ulcers from taking nonsteroidal anti-inflammatory drugs (NSAIDs) alone. Diclofenac is a NSAID used in this combination medicine to help relieve some symptoms of arthritis, such as inflammation, swelling, stiffness, and joint pain. Misoprostol is used in this combination medicine to prevent stomach ulcers. Avoid prolonged exposure to sunlight. |
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Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication. If you experience any of the following serious side effects, stop taking diclofenac and misoprostol and seek medical treatment or call your doctor immediately: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); severe diarrhea, abdominal cramping, indigestion, or heartburn; jaundice (yellowing of the skin and eyes), nausea and upper abdominal tenderness, a flulike feeling, unusual fatigue, and itching; ulcers (open sores) in the mouth; rapid weight gain (fluid retention); seizures; black, bloody, or tarry stools; blood in your urine or vomit; decreased hearing or ringing in the ears. Other, less serious side effects may be more likely to occur. Continue to take diclofenac and misoprostol and talk to your doctor if you experience: nausea, gaseousness, or abdominal pain; diarrhea; dizziness or headache; fatigue or weakness; dry mouth; irregular menstrual periods. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Before taking this medication, tell your doctor if you: have an allergy to any other NSAID or to aspirin; have an ulcer or bleeding in your stomach; drink more than three alcoholic beverages a day; have liver or kidney disease; have a coagulation (bleeding) disorder; have congestive heart failure; have fluid retention; have heart disease, have high blood pressure. You may not be able to take diclofenac and misoprostol, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. Diclofenac and misoprostol is in the FDA pregnancy category X. This means that it is known to harm an unborn baby. Misoprostol can induce a miscarriage or a spontaneous abortion.Do not take diclofenac and misoprostol if you are pregnant or if you are planning a pregnancy. Do not share this medication with any one else. Your doctor will ask you to have a pregnancy test before you start treatment with diclofenac and misoprostol, and therapy will begin only after your next regular menstrual cycle begins. Also, you will need to use appropriate contraception to prevent pregnancy during your therapy. Diclofenac passes into breast milk and may affect a nursing baby. It is not known whether misoprostol passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. Keep Arthrotec in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. To reduce the incidence of diarrhea, do not take antacids that contain magnesium while you are taking diclofenac and misoprostol. If you need an antacid, take one with aluminum or calcium instead of magnesium. Before taking diclofenac and misoprostol, tell your doctor if you are taking any of the following medicines: another nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin); aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), bismuth subsalicylate (Pepto-Bismol), choline salicylate, or magnesium salicylate (watch the aspirin content of other over-the-counter products such as cough, cold, and allergy medicines); a diuretic (water pill) such as hydrochlorothiazide (Hydrodiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Hygroton, Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), triamterene (Dyrenium, Dyazide, Maxzide), or amiloride (Midamor); an angiotensin-converting-enzyme (ACE) inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), or ramipril (Altace); a beta-blocker such as acebutolol (Sectral), metoprolol (Lopressor), propranolol (Inderal), atenolol (Tenormin), or carteolol (Cartrol); an anticoagulant such as warfarin (Coumadin); insulin or an oral diabetes drug such as glipizide (Glucotrol) or glyburide (Micronase, Diabeta); a steroid such as prednisone (Orasone, Deltasone, others), methylprednisolone (Medrol), dexamethasone (Decadron), prednisolone (Prelone, others), and others; digoxin (Lanoxin); phenobarbital (Luminal, Solfoton); lithium (Eskalith, Lithobid, others); cyclosporine (Sandimmune, Neoral); tacrolimus (Prograf); methotrexate (Rheumatrex); alcohol. You may not be able to take diclofenac and misoprostol, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with diclofenac and misoprostol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
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