CLOMIPHENE
Generic Name: clomiphene (KLOE mih feen) Brand Names: Clomid, Serophene
Use clomiphene exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you. Take each dose with a full glass of water. Clomiphene is usually taken in 5 day cycles. Follow your doctor's instructions. Store clomiphene at room temperature, away from direct light, moisture, and heat. Clomiphene stimulates the release of hormones necessary for ovulation to occur. Clomiphene is used to stimulate ovulation (the release of an egg) when a woman's ovaries can produce a follicle but hormonal stimulation is deficient. Clomiphene may also be used for purposes other than those listed in this medication guide.  Clomiphene (KLOE-mi-feen) is used as a fertility medicine in some women who are unable to become pregnant. Clomiphene probably works by changing the hormone balance of the body. In women, this causes ovulation to occur and prepares the body for pregnancy. Clomiphene may also be used for other conditions in both females and males as determined by your doctor. The following information applies only to female patients taking clomiphene. Check with your doctor if you are a male and have any questions about the use of clomiphene. |
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Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication. Side effects occur infrequently and generally do not interfere with treatment at the recommended dosage of clomiphene. They tend to occur more frequently at higher doses and during long-term treatment. More common side effects include: Abdominal discomfort, enlargement of the ovaries, hot flushes. Less common side effects include: Abnormal uterine bleeding, breast tenderness, depression, dizziness, fatigue, hair loss, headache, hives, inability to fall or stay asleep, increased urination, inflammation of the skin, light-headedness, nausea, nervousness, ovarian cysts, visual disturbances, vomiting, weight gain. Your doctor will evaluate you for normal liver function and normal estrogen levels before considering you for treatment with clomiphene. Your doctor will also examine you for pregnancy, ovarian enlargement, or cyst formation prior to treatment with this drug and between each treatment cycle. He or she will do a complete pelvic examination before each course of this medication. Clomiphene treatment increases the possibility of multiple births; also, birth defects have been reported following treatment to induce ovulation with clomiphene, although no direct effects of the drug on the unborn child have been established. Because blurring and other visual symptoms may occur occasionally with clomiphene treatment, you should be cautious about driving a car or operating dangerous machinery, especially under conditions of variable lighting. If you experience visual disturbances, notify your doctor immediately. Symptoms of visual disturbance may include blurring, spots or flashes, double vision, intolerance to light, decreased visual sharpness, loss of peripheral vision, and distortion of space. Your doctor may recommend a complete evaluation by an eye specialist. Ovarian hyperstimulation syndrome (or OHSS, enlargement of the ovary) has occurred in women receiving treatment with clomiphene. OHSS may progress rapidly and become serious. The early warning signs are severe pelvic pain, nausea, vomiting, and weight gain. Symptoms include abdominal pain, abdominal enlargement, nausea, vomiting, diarrhea, weight gain, difficult or labored breathing, and less urine production. If you experience any of these warning signs or symptoms, notify your doctor immediately. To lessen the risks associated with abnormal ovarian enlargement during treatment with clomiphene, the lowest effective dose should be prescribed. Women with the hormonal disorder, polycystic ovarian syndrome, may be unusually sensitive to certain hormones and may respond abnormally to usual doses of this drug. If you experience pelvic pain, notify your doctor. He may discontinue your use of clomiphene until the ovaries return to pretreatment size. Because the safety of long-term treatment with clomiphene has not been established, your doctor will not prescribe more than about 6 courses of therapy. Prolonged use may increase the risk of a tumor in the ovaries. Keep Clomiphene in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. There are no known interactions between clomiphene and other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
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