ESTRACE
Generic Name: estradiol (oral, injectable, and vaginal) (ess tra DYE ole) Brand Names: Clinagen LA 40, Delestrogen, Depo-Estrace, Estrace, Femring, Gynodiol, Valergen
Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Estrace may be administered by mouth, injection, or inserted as a ring into the vagina. Your healthcare provider may administer injections of estrace or will provide you with detailed instructions on how to administer the medication at home. Take each oral dose with a full glass of water. Take oral estrace with food or milk to lessen stomach upset. Try to take oral doses at the same time daily. Use injectable estrace exactly as directed by your healthcare provider. Do not inject any estrace product that is discolored or has particles in it. Injectable estrace stored at cool temperatures may develop crystals in the solution, which should dissolve as the solution warms to room temperature. Rotate injection sites as directed. Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture resistant disposal container. The Femring vaginal ring is inserted into the vaginal by you or your healthcare provider. To use the Femring vaginal ring: - Wash and dry your hands. Remove Femring from the pouch. - Squeeze the sides of the ring together or squeeze it into a figure-eight shape. Push the folded ring into the vagina (up and towards the lower back) as far as possible (into the upper 1/ 3 of the vagina). You should not be able to feel the ring once it is in position. If you can feel it, use a finger to push it further into the vagina. It is not possible for the ring to go too far in or become lost. - The ring should remain in place for 3 months. It should then be removed and replaced by a new ring, if prescribed by your doctor. To remove the ring, loop a finger through the ring and gently pull it from the vagina. - The ring does not need to be removed during sexual intercourse. It should not be felt by either partner. If it is bothersome, it can be removed, rinsed with warm water, and reinserted following intercourse. - If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it. If the ring falls out repeatedly, talk to your doctor. It is important to use estrace regularly to get the most benefit. Your doctor may want you to have regularly scheduled blood tests or other medical evaluations during treatment with estrace to monitor progress and side effects. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking estrace. Store estrace at room temperature away from moisture, heat, and direct light. Estrogens ( ES-troe-jenz) are female hormones. They are produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years. The ovaries begin to produce less estrogen after menopause (the change of life). This medicine is prescribed to make up for the lower amount of estrogen. Estrogens help relieve signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness.  Estrace increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with estrace lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with estrace long-term may increase the risk of stroke. |
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Use the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and use only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor. Estrace increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with estrace lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with estrace long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking estrace long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. If you experience any of the following serious side effects, stop taking estrace and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); shortness or breath or pain in the chest; a painful, red, or swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache or vomiting, dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes; a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to take estrace and talk to your doctor if you experience: decreased appetite, nausea, or vomiting; swollen or tender breasts; acne or skin color changes; decreased sex drive; migraine headaches or dizziness; water retention (swollen hands, feet, or ankles); problems with wearing contact lenses; depression; changes in menstrual cycle or breakthrough bleeding. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects . These visits will usually be every year, but some doctors require them more often. In some patients using estrogens, tenderness, swelling, or bleeding of the gums may occur. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your medical doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums. Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast, ovaries, or uterus (womb).. Therefore, it is very important that you regularly check your breasts for any unusual lumps or discharge. Report any problems to your doctor. You should also have a mammogram (x-ray pictures of the breasts) done if your doctor recommends it. Because breast cancer has occurred in men taking estrogens, regular breast self-exams and exams by your doctor for any unusual lumps or discharge should be done. If your menstrual periods have stopped, they may start again. This effect will continue for as long as the medicine is taken. However, if taking the continuous treatment (0.625 mg conjugated estrogens and 2.5 mg medroxyprogesterone once a day), monthly bleeding usually stops within 10 months. Also, vaginal bleeding between your regular menstrual periods may occur during the first 3 months of use. Do not stop taking your medicine. Check with your doctor if bleeding continues for an unusually long time, if your period has not started within 45 days of your last period, or if you think you are pregnant. Tell the doctor in charge that you are taking this medicine before having any laboratory test because some results may be affected. Keep Estrace in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. Before taking estrace, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); a thyroid medication such as Synthroid, Levoxyl, Levothroid, and others; insulin or an oral diabetes medicine such as glipizide (Glucotrol) or glyburide (Diabeta, Micronase); tamoxifen (Nolvadex); didanosine (Videx); phenytoin (Dilantin) or ethotoin (Peganone); carbamazepine (Tegretol); phenobarbital (Solfoton, Luminal); primidone (Mysoline); rifampin (Rifadin). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with estrace. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
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