INDOMETHACIN
Generic Name: indomethacin (in doe METH a sin) Brand Names: Indocin, Indocin SR Indomethacin (USAN) or indometacin (INN) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms. It is marketed under many trade names, including Indocin, Indocid, Indochron E-R, and Indocin-SR.
Indomethacin comes as a regular capsule, extended-release (long-acting) capsule, and a liquid to take by mouth and suppositories to be used rectally. Indomethacin capsules, liquid, and suppositories usually are taken two to four times a day; extended-release capsules are taken one or two times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take indomethacin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Extended-release capsules should be swallowed whole; do not open them to mix with food or beverages. Shake the oral liquid well before each use. Indomethacin is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin works by reducing hormones that cause inflammation and pain in the body. Indomethacin is used to reduce the pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis, tendinitis, and bursitis. Indomethacin may also be used for purposes not listed in this medication guide.  Indomethacin is a nonselective inhibitor of cyclooxygenase (COX) 1 and 2, enzymes that participate in prostaglandin synthesis from arachidonic acid. Prostaglandins are hormone-like molecules normally found in the body, where they have a wide variety of effects, some of which lead to pain, fever, and inflammation. Prostaglandins also cause uterine contractions in pregnant women. Indomethacin is an effective tocolytic agent, able to delay premature labor by reducing uterine contractions through inhibition of PG synthesis in the uterus and possibly through calcium channel blockade. |
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If you are taking indomethacin on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose. If you are taking indomethacin as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose. Side effects that you should report to your prescriber or health care professional as soon as possible: signs of bleeding from the stomach - black tarry stools, blood in the urine, unusual tiredness or weakness, vomiting blood or vomit that looks like coffee grounds; signs of an allergic reaction - difficulty breathing or wheezing, skin rash, redness, blistering or peeling skin, hives, or itching, swelling of eyelids, throat, lips; blurred vision; change in the amount of urine passed; difficulty swallowing, severe heartburn or burning, pain in throat; pain or difficulty passing urine; stomach pain or cramps; swelling of feet or ankles. Avoid prolonged exposure to sunlight. Indomethacin may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, indomethacin may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking indomethacin if you drink more than 3 alcoholic beverages a day. Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to indomethacin (such as ibuprofen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist. Keep Indomethacin in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. Before taking indomethacin, tell your doctor if you are taking any of the following drugs: aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, others); another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn, Anaprox, others), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin); an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, indomethacin, or ketoprofen; an anticoagulant (blood thinner) such as warfarin (Coumadin); a steroid such as prednisone (Deltasone); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; probenecid (Benemid); lithium (Eskalith, Lithobid, others); bismuth subsalicylate in drugs such as Pepto-Bismol. You may not be able to take indomethacin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with indomethacin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
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