MUSE
Generic Name: alprostadil (injectable and transurethral) (al PROS ta dill) Brand Names: Caverject, Edex, Muse ALPROSTADIL is used for the treatment of erectile dysfunction, commonly called impotence. Alprostadil helps to create and maintain an erection. MUSE® is designed to deliver alprostadil across the urethra (the normal pathway for urine) and into the erectile tissue. Generic alprostadil is not yet available.
Immediately before using, urinate and gently shake the penis several times to remove excess urine. A moist urethra makes using MUSE® easier. The medicated pellet has been specially developed to dissolve in the small quantity of urine that remains in the urethra after urination. Open pouch and remove the protective cap from the applicator stem. Visually inspect the MUSE® system to make sure the pellet is in the end of the stem. Save the pouch for discarding the applicator later. While sitting or standing, whichever is more comfortable, take several seconds to gently and slowly stretch the penis upward to its full length, with gentle compression from top to bottom of the glans. This straightens and opens the urethra. Slowly insert the MUSE® stem into the urethra up to the collar. If any discomfort or a pulling sensation, withdraw the applicator slightly and then gently reinsert. Administer the suppository by gently and completely push down the button at the top of the applicator until it stops. This is to make sure that the medicated pellet is completely released. Hold the applicator in this position for 5 seconds. Then, gently rock the applicator from side to side in order to separate the medicated pellet from the applicator tip. If you apply too much pressure you may scratch the lining of the urethra and cause it to bleed. Remove the applicator while keeping the penis upright. Without touching the stem of the applicator, look at the applicator tip to make sure the pellet is no longer in the applicator. If any medication is present, gently reinsert into the urethra and repeat steps 2—5. After administration, hold the penis upright and stretch to its full length. Roll the penis firmly between the hands for at least 10 seconds. This is to make sure that the medication is adequately distributed along the walls of the urethra. If a burning sensation is felt, continue to roll the penis for an additional 30—60 seconds or until the burning subsides. To increase blood flow to the penis and help you get an erection, you should sit, stand, or walk about for 10 minutes while the erection is developing. Replace the cap on the MUSE® applicator, place the applicator in the opened foil pouch, fold, and discard as normal household waste. Muse helps to create and maintain an erection. Muse is designed to deliver alprostadil across the urethra (the normal pathway for urine) and into the erectile tissue. Generic alprostadil is not yet available.  Do not use more Muse than is prescribed for you. Too much Muse can be very dangerous. Notify your doctor if Muse is not treating your symptoms. An erection should result 5 to 20 minutes after a dose. Contact your doctor or seek emergency medical attention for any erection that lasts for 4 hours. A sustained erection can damage the penis. Use a condom to prevent transfer of this medication if your partner is pregnant. |
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Since Muse is used as needed, missing a dose is not usually an issue. More common side effects may include: Extremely low blood pressure, flu symptoms, headache, infection, pain, penis bleeding, penis burning or pain, testicular pain. Less common side effects may include: Back pain, dizziness, leg pain, pain in the area behind the testicles, pelvic pain, rapid pulse, runny nose, swelling of leg veins. Muse may cause vaginal burning and itching in your partner. Do not use Muse without first talking to your doctor if you have: sickle cell anemia or the sickle cell anemia trait; leukemia; a tumor of the bone marrow (multiple myeloma); a penile implant; penile deformation or curvature; ; penile fibrosis or Peyronie's disease. You may not be able to use Muse, or you may require a dosage adjustment or special monitoring during therapy. Muse should not be used by women. Do not use this medication if you are pregnant or are breast-feeding a baby. Use a condom to prevent transfer of this medication if your partner is pregnant or could become pregnant during treatment. Muse should not be used by children. Keep Muse in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. Before using Muse, tell your doctor if you are taking a blood-thinning medicine such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), or enoxaparin (Lovenox). There may be an increased risk of bleeding with injection or insertion of Muse, and special monitoring may be needed. Also, before using Muse, tell your doctor if you are taking cyclosporine (Neoral, Sandimmune, Gengraf). You may require a dosage adjustment or special monitoring during treatment if you use Muse during treatment with cyclosporine. Drugs other than those listed here may also interact with Muse or affect your condition. Talk to your doctor and pharmacist before using any prescription or over-the-counter medicines, including herbal products.
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