PERCOCET
Oxycodone is a very powerful and potentially addictive opioid analgesic medication synthesized from thebaine.
It is effective orally and is marketed in combination with aspirin (Percodan, Endodan, Roxiprin) or acetaminophen (Percocet, Endocet, Roxicet, Tylox) for the relief of pain. More recently, ibuprofen has been added to oxycodone (Combunox). It is also sold in a sustained-release form by Purdue Pharma under the trade name OxyContin as well as generic equivalents, and instant-release forms OxyIR, OxyNorm, Percolone, OxyFAST, and Roxicodone.
Percocet comes as a liquid and tablet to take by mouth. It usually is taken every 6 hours as needed; extended-release (long-acting) tablets usually are taken every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Percocet exactly as directed. Swallow the extended-release tablet whole. Do not chew, break, or crush extended-release Percocet tablets. Percocet can be habit-forming. Do not take a larger dose, take it more often, or for a longer period than your doctor tells you to. If you have been taking Percocet for more than a few weeks, do not stop taking Percocet suddenly. Your doctor probably will decrease your dose gradually. Do not stop taking acetaminophen and Percocet suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose. Use caution when driving, operating machinery, or performing other hazardous activities. Percocet may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol while taking acetaminophen and Percocet. Alcohol may increase the drowsiness and dizziness caused by acetaminophen and Percocet and could be dangerous. Also, acetaminophen can be toxic to your liver when taken with as little as 2 drinks of alcohol. Also avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These medications also may cause dangerous sedation. Acetaminophen and Percocet may cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet can also help to alleviate constipation. Never take more acetaminophen and Percocet than is prescribed for you. If your pain is not being adequately treated, talk to your doctor. Watch the acetaminophen content of other over-the-counter and prescription products while taking this medication. Do not take more than a total of 4 grams (4000 mg) of acetaminophen per day.  Percocet (related to codeine) is in a class of drugs called narcotic analgesics. It relieves pain. Acetaminophen is a less potent pain reliever that increases the effects of Percocet. Together, acetaminophen and Percocet are used to relieve moderate-to-severe pain. Acetaminophen and Percocet may also be used for purposes other than those listed in this medication guide. |
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Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication. If you experience any of the following serious side effects, stop taking acetaminophen and Percocet and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); slow, weak breathing; seizures; cold, clammy skin; severe weakness or dizziness; unconsciousness; yellowing of the skin or eyes; unusual fatigue, bleeding, or bruising. Other, less serious side effects may be more likely to occur. Continue to take acetaminophen and Percocet and talk to your doctor if you experience: constipation; dry mouth, nausea, vomiting, or decreased appetite; dizziness, tiredness, or lightheadedness; muscle twitches; sweating; itching; decreased urination; decreased sex drive. Acetaminophen and Percocet is habit forming. Do not stop taking it suddenly. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Use caution when driving, operating machinery, or performing other hazardous activities. Percocet may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol while taking acetaminophen and Percocet. Alcohol may increase the drowsiness and dizziness caused by acetaminophen and Percocet and could be dangerous. Also, acetaminophen can be toxic to your liver when taken with as little as 2 drinks of alcohol. Also avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These medications also may cause dangerous sedation. Watch the acetaminophen content of other over-the-counter and prescription products while taking this medication. Do not take more than a total of 4 grams (4000 mg) of acetaminophen per day. Keep Percocet in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. Do not take acetaminophen and Percocet if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result. The most serious interactions affecting acetaminophen and Percocet are with those drugs that also cause sedation. The following drugs may lead to dangerous sedation if taken with acetaminophen and Percocet: antihistamines such as brompheniramine (Dimetane, Bromfed, others), diphenhydramine (Benadryl, Nytol, Compoz, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), and others; tricyclic antidepressants, such as amitriptyline (Elavil) and doxepin (Sinequan), and serotonin reuptake inhibitors such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil); other commonly used antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), and protriptyline (Vivactil); anticholinergics such as belladonna (Donnatal), clidinium (Quarzan), dicyclomine (Bentyl, Antispas), hyoscyamine (Levsin, Anaspaz), ipratropium (Atrovent), propantheline (Pro-Banthine), and scopolamine (Transderm-Scop); phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), thioridazine (Mellaril), and prochlorperazine (Compazine); tranquilizers and sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), secobarbital (Seconal), alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), flurazepam (ProSom), and temazepam (Restoril). You may not be able to take acetaminophen and Percocet or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. Watch the acetaminophen content of other over-the-counter and prescription products while taking this medication. Do not take more than a total of 4 grams (4000 mg) of acetaminophen per day. Drugs other than those listed here may also interact with acetaminophen and Percocet. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
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