PHENTERMINE
Phentermine is one of two drugs in the Fen-phen anti-obesity medication, the other being fenfluramine or dexfenfluramine. Fenfluramine was withdrawn from the U.S. market in 1997 after reports of valvular heart disease and pulmonary hypertension.
Phentermine is still available by itself in most countries, including the U.S. However, because it is similar to the amphetamines, individuals may develop an addiction to it. Hence, it is classified as a controlled substance in many countries. Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act.
Take Phentermine on an empty stomach, once daily, 30-60 minutes before breakfast. Do not increase your dose or take it more often than prescribed because this drug can be habit forming. Also, if used for a longer period of time, do not suddenly stop this medication without first consulting your doctor. This medication is usually taken for 8 to 12 weeks. Generally, it is recommended by the FDA that phentermine should be used short-term (usually interpreted as 'up to 12 weeks'), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. However, recommendations limiting its use for short-term treatment may be controversial. One reason given behind limiting its use to 12 weeks is drug tolerance, whereby phentermine loses its appetite-suppressing effects after the body adjusts to the drug. On the contrary, it has been shown that phentermine did not lose effectiveness in a 36-week trial (PMID 11054601). However, the risk of drug addiction may be a significant reason in limiting phentermine for short-term use.  Phentermine, as many other prescription drugs, works with neurotransmitters in the brain. It is a centrally-acting stimulant chemically related to the amphetamines. It stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines; these include dopamine, epinephrine (also known as adrenalin), and norepinephrine (noradrenaline). This is the same mechanism of action as other stimulant appetite suppresants such as sibutramine, diethylpropion, and dextroamphetamine. The neurotransmitters signal a fight-or-flight response in the body which, in turn, puts a halt to the hunger signal. As a result, it causes a loss in appetite because the brain does not receive the hunger message. |
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If you neglect taking a dose of Phentermine, do not take twice the amount at the next dosing. Remain on your normal dosing schedule by simply skipping the missed dose. Because phentermine acts through sympathomimetic pathways, the drug may increase blood pressure and heart rate. It may also cause palpitations, restlessness, and insomnia. Additionally, individuals taking this drug on a long-term basis may develop euphoria and a psychological addiction to it. Heart valve damage and pulmonary hypertension, severe enough to cause permanent disability or death have been seen with phentermine alone. Tell your doctor your complete medical history especially if you have high blood pressure, an over-active thyroid, glaucoma, diabetes or emotional problems. Consult with your doctor if you think you are pregnant or before breast-feeding. Alcohol can increase unwanted side effects of dizziness. Limit alcohol use. This drug is not recommended for use in children. Consult your doctor or pharmacist for further information. The only thing you need to do is store it at room temperature; keep it away from sunlight and moisture. Also keep this medication out of the reach of children. Notify your doctor about all prescription and nonprescription medications you use, particularly other weight loss medications, those for the treatment of high blood pressure, or any MAO inhibitors (e.g., furazolidone, phenelzine, selegiline, tranylcypromine). Do not use drugs that my increase your heart rate or blood pressure. Caffeine and decongestants are such istimulantî drugs. Decongestants are frequently included in cough and cold medicines available over-the-counter.
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