
PREMPRO
Prempro are naturally occurring female sex hormones that are involved in the development and maintenance of the female reproductive system. Medroxyprogesterone is a female hormone, usually called "progesterone." It is important for the regulation of ovulation and menstruation. Together, conjugated estrogen and progesterone are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"); to treat vulvar and vaginal changes caused by menopause (itching, burning, dryness in or around the vagina, difficulty or burning with urination); and to prevent thinning of the bones (osteoporosis). Conjugated estrogen and Prempro may also be used for purposes other than those listed in this medication guide.
The Women's Health Initiative (WHI) study found an increased risk of breast cancer, heart disease, nonfatal heart attacks, and blood clots in women taking estrogen and Prempro long-term. You should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking a conjugated estrogen and medroxyprogesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Take conjugated estrogen and Prempro exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take conjugated estrogen and Prempro with food or milk to lessen stomach upset. Try to take doses at the same time each day. You may be taking the medication on a cycle, such as every day for 3 weeks with 1 week off each month to mimic the body's natural cycle. Follow the directions on the prescription label. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking a conjugated estrogen and medroxyprogesterone combination. It is important to take conjugated estrogen and Prempro regularly to get the most benefit. Your doctor may want you to have blood tests or other medical evaluations during treatment with a conjugated estrogen and medroxyprogesterone combination to monitor progress and side effects. Store conjugated estrogen and Prempro at room temperature away from moisture and heat. ![]() Before taking conjugated estrogen and Prempro, tell your doctor if you have: high blood pressure, angina, or heart disease; a history of heart attack or stroke; high levels of cholesterol or triglycerides in the blood; kidney disease; thyroid problems; asthma; epilepsy; migraines; depression; diabetes; gallbladder disease; uterine fibroids; had a hysterectomy (uterus removed). You may not be able to take conjugated estrogen and Prempro, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. |
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Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and return to the regular dosing schedule. Do not take a double dose of this medication unless otherwise directed by your doctor. Prempro increase the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Taking a progestin, such as medroxyprogesterone, with Prempro lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. Stop taking the conjugated estrogen and medroxyprogesterone combination and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); a blood clot (pain, redness, and swelling in an arm or leg; shortness of breath; coughing blood; chest pain; headache; blurred vision; confusion; loss of speech, or dizziness); unusual or abnormal vaginal bleeding; gallbladder disease (pain, swelling, or tenderness in the abdomen); liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); a lump in a breast. Prempro increase the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Taking a progestin, such as medroxyprogesterone, with Prempro lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. The Women's Health Initiative (WHI) study found an increased risk of breast cancer, heart disease, nonfatal heart attacks, and blood clots in women taking estrogen and Prempro long-term. You should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking a conjugated estrogen and medroxyprogesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking conjugated estrogen and Prempro. Do not take conjugated estrogen and Prempro if you are pregnant or planning to become pregnant. It could affect the development of the baby. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. Before taking a conjugated estrogen and medroxyprogesterone combination, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; tamoxifen (Nolvadex). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with conjugated estrogen and Prempro. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
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