SILDENAFIL
Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections (Boolell et al 1996). Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the FDA on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year (Kling 1998). It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion.
Sildenafil comes as a tablet to take by mouth. It should be taken as needed about 1 hour before sexual activity. However, sildenafil can be taken anytime from 4 hours to 30 minutes before sexual activity. Sildenafil should not be taken more than once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sildenafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Sildenafil is used to treat impotence in men. Sildenafil increases the body's ability to achieve and maintain an erection during sexual stimulation. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.  The name "Viagra", like many drug names, is a marketing invention. It was possibly inspired by the Sanskrit word "vyaghra", which means "tiger". The word rhymes with "Niagara" (Niagara Falls is a popular honeymoon destination and Niagara, being such an impressive waterfall, evokes a sense of incredible erectile and ejaculatory strength). The sound of the word also suggests the words "vigor" and "virile" |
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Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; constipation; diarrhea; gas; bloating or fullness in the stomach; change in ability to taste food; pain in bones, muscles, or joints; headache; Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately. It is very important to talk to your doctor right away after you develop these symptoms to be sure you do not develop a serious condition:; new or worsening heartburn; difficulty swallowing or pain when swallowing; chest pain; upset stomach; vomiting; bloody vomit or vomit that looks like coffee grounds; black, tarry, or bloody stools; mouth sores or pain in the mouth (especially if you chew or suck on tablets); rash (may be severe and may be made worse by sunlight); itching; hives; swelling of eyes, face, lips, tongue, or throat; difficulty breathing or swallowing; hoarseness; eye pain; flu-like symptoms; fever. Sildenafil is metabolised by hepatic enzymes and excreted by both the liver and kidneys. If taken with a high fat meal, there may be a delay in absorption of sildenafil and the peak effect might be reduced slightly as the plasma concentration will be lowered. Some reports have claimed that sildenafil causes enhanced sexual pleasure for women by increasing blood flow to the sexual organs. This lacks firm evidence, and it has also been suggested that this is part of an effort to invent a new disease - female sexual dysfunction - thus doubling the potential size of the market for this class of drugs. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze alendronate solution. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
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